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Paula Deen Chicken Casserole: The Creamy Southern Classic You’ll Make Again

Maya

By Maya

Mar 9, 2026

15 min prep
30 min cook
8 servings
Jump to Recipe
Paula Deen Chicken Casserole: The Creamy Southern Classic You’ll Make Again

Welcome to a delicious journey through Southern comfort food with Paula Deen's Chicken Casserole! This dish is the epitome of creamy, cheesy goodness that will warm your heart and fill your home with enticing aromas. Perfect for family gatherings or a cozy weeknight dinner, this casserole is easy to prepare and even easier to love.

With layers of tender chicken, al dente pasta, and a luscious cheese sauce, this recipe is a surefire hit. As it bakes, the top becomes golden and crispy, while the inside stays melt-in-your-mouth creamy. Let's dive into why this dish deserves a spot in your recipe repertoire!

Why You'll Love This Recipe

  • Ultimate Comfort Food: This casserole embodies the warmth and comfort of Southern cooking.
  • Family-Friendly: A hit with both kids and adults, making mealtime stress-free.
  • Versatile Ingredients: Use rotisserie chicken and your favorite pasta for a quick, satisfying dish.
  • Deliciously Cheesy: The combination of cheeses creates a gooey, flavorful topping that you won't be able to resist!

About the Ingredients

Cooked Chicken

Rotisserie chicken works beautifully here, saving time and adding rich flavor to the dish.

Cooked Pasta

Penne, rigatoni, or cavatappi all hold the creamy sauce well, making every bite satisfying.

Unsalted Butter

This is the base for the sauce, providing a rich, savory flavor that enhances the entire casserole.

Onion

A finely chopped onion adds sweetness and depth to the flavor profile of the dish.

Garlic

Fresh garlic brings a fragrant, aromatic quality that elevates the overall taste of the casserole.

Sour Cream

This ingredient adds a tangy creaminess that balances out the richness of the cheese sauce.

Tips & Tricks

Use Quality Cheese

Opt for a good quality cheddar or Colby Jack for the best melt and flavor.

Don’t Skip the Resting Time

Letting the casserole rest for a few minutes after baking allows the flavors to meld beautifully.

Mix Up Your Toppings

Crushed Ritz crackers or breadcrumbs add crunch and texture that contrast nicely with the creamy filling.

Season to Taste

Don’t hesitate to adjust the salt and pepper according to your preference for a more personalized flavor.

Pro Tips

  • Use Room Temperature Ingredients: Allow sour cream and milk to sit out for a bit for a smoother sauce.
  • Prep Ahead: Assemble the casserole a day in advance and bake it when ready to serve.
  • Experiment with Herbs: Fresh parsley or chives can add a lovely pop of color and flavor to your dish.
  • Check for Bubbling: Ensure the casserole is bubbling and slightly browned before taking it out of the oven for that perfect finish.

Step-by-Step Instructions

Preheat Your Oven

Start by preheating your oven to 350°F (175°C) and lightly grease a 9x13-inch baking dish.

Sauté the Aromatics

In a large skillet, melt the butter over medium heat. Add diced onion and sauté until soft and fragrant—about 3 minutes. Stir in minced garlic and cook for an additional 30 seconds.

Create the Cheese Sauce

Sprinkle the flour over the onion mixture and stir for about a minute. Gradually whisk in the milk until the mixture is smooth and slightly thickened. Reduce the heat, then stir in sour cream, 3 cups of cheese, red pepper flakes, salt, and pepper.

Combine Pasta and Chicken

In a large mixing bowl, combine the cooked pasta, chopped chicken, and the cheese sauce. Toss gently until every piece is beautifully coated.

Bake to Perfection

Spread the mixture evenly into the prepared baking dish. Sprinkle the remaining 1/2 cup cheese on top and bake uncovered for 20-25 minutes, until bubbling and lightly browned.

Delicious Variations

Vegetable Add-Ins

Add steamed broccoli or spinach for a nutritious twist that adds color and flavor.

Spicy Kick

Incorporate diced jalapeños or a dash of hot sauce for those who enjoy a little heat.

Different Proteins

Swap out the chicken for turkey or leftover ham for a delightful change!

How to Store Paula Deen Chicken Casserole

Refrigerator

Store leftovers in an airtight container for up to 3 days.

Freezer

Freeze the casserole unbaked for up to 2 months; just thaw and bake when ready.

Reheating

Reheat individual portions in the microwave or warm the entire dish in the oven at 350°F until heated through.

Frequently Asked Questions

Can I use uncooked chicken?

Yes, but make sure to cook it thoroughly before combining with the other ingredients.

What type of cheese is best?

A blend of cheddar and Colby Jack gives the best flavor and texture, but feel free to experiment!

Can I make this casserole gluten-free?

Absolutely! Substitute regular pasta with gluten-free pasta and use gluten-free flour for the sauce.

How can I make it more creamy?

Add extra sour cream or use half-and-half instead of milk for a richer sauce.

Now that you have all the secrets to making this fabulous Paula Deen Chicken Casserole, gather your loved ones around the table and enjoy a comforting meal that will surely become a family favorite. Happy cooking!

Paula Deen Chicken Casserole: The Creamy Southern Classic You’ll Make Again

Paula Deen Chicken Casserole: The Creamy Southern Classic You’ll Make Again

Try this Paula Deen Chicken Casserole for the ultimate creamy, cheesy comfort food. Easy to make, family-friendly, and full of Southern flavor.

15 min
Prep Time
30 min
Cook Time
8
Servings
520 kcal
Calories

Ingredients

Instructions

  1. 1 Preheat the oven to 350°F (175°C) and lightly grease a 9x13-inch baking dish.
  2. 2 In a large skillet, melt the butter over medium heat. Add diced onion and sauté until soft and fragrant — about 3 minutes. Stir in minced garlic and cook for 30 seconds more.
  3. 3 Sprinkle the flour over the onion mixture and stir for about a minute. Gradually whisk in milk until smooth and slightly thickened. Reduce the heat, then stir in sour cream, 3 cups of cheese, red pepper flakes, salt, and pepper.
  4. 4 In a large mixing bowl, combine cooked pasta, chopped chicken, and the cheese sauce. Toss gently until every piece is coated.
  5. 5 Spread the mixture evenly into the prepared baking dish. Sprinkle the remaining 1/2 cup cheese on top. Bake uncovered for 20-25 minutes, until bubbling and lightly browned.
  6. 6 Let the casserole rest for about 5 minutes before serving.

Chef's Note

Store leftovers in an airtight container for up to 3 days. You can freeze the assembled casserole before baking for up to 2 months. Thaw overnight in the fridge before baking.

Servings: 8

Cuisine: American

Course: Main Course

Nutrition (per serving): 28gg protein